Erythropoietin: Production by a Particulate Fraction of Rat Kidney

Science  29 Apr 1966:
Vol. 152, Issue 3722, pp. 653-654
DOI: 10.1126/science.152.3722.653


An erythropoietic factor was extracted with hypotonic phosphate buffer from the kidneys of hypoxic rats. Normal rat serum enhanced the activity of this factor, which is associated with the light mitochondrial fraction. The data suggest that the renal factor is not physiologically active unless it interacts with a serum carrier or activator, or that the factor may be an enzyme which produces erythropoietin from some serum substrate.