Immunochemical Characterization of Polyribonucleotides

Science  06 May 1966:
Vol. 152, Issue 3723, pp. 773-775
DOI: 10.1126/science.152.3723.773


The degree of organization of polyribonucleotides determines their modalities of reaction with antibodies (NG-I) which are present in serums of animals hyperimmunized with ribosomes. The immunochemical behavior of the highly helical two-stranded complex of polyadenylic acid and polyuridylic acid and the corresponding three-stranded complex of one molecule of polyadenylic acid and two molecules of polyuridylic acid can be determined from examination of the associatinge and nonassociating mixtures of polyadenylic and polyuridylic acids. The immunochemical characteristics of various forms of polyinosinic acid in solution are described.