Estrous Cycle in the Rat: Effects on Self-Stimulation Behavior

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Science  06 May 1966:
Vol. 152, Issue 3723, pp. 796-797
DOI: 10.1126/science.152.3723.796


The performance of female rats, in pressing a bar for electrical stimulation of the hypothalamus, changes during the estrous cycle. Highest barpressing rates accompany the appearance of vaginal cornification. This increase is not an artifact of increased spontaneous activity at estrus, although the factors underlying these changes in activity may also mediate the changes in self-stimulation behavior.