Stable Complex of Fibrinogen and Fibrin

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Science  20 May 1966:
Vol. 152, Issue 3725, pp. 1069-1071
DOI: 10.1126/science.152.3725.1069


Fibrin-stabilizing factor acts on monomeric fibrin combined with fibrinogen to form a stable complex that is soluble at physiologic pH and ionic strength. The complex has been isolated by chromatography on agarose gel and characterized by sedimentation rate near 24 Sw.20 at both pH 5.3 and 7.4, by coagulability when treated with thrombin, and by content of fibrinopeptides. Formation of the complex could provide a pathway for solubilization of monomeric fibrin produced in circulating blood.