Murine Leukemia Viruses: Antigenic Studies by Quantitative Complement Fixation

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Science  20 May 1966:
Vol. 152, Issue 3725, pp. 1074-1075
DOI: 10.1126/science.152.3725.1074


The murine leukemia viruses of Rauscher and Friend, derived from plasnma of infected Balb/c mice, was purified. Their antigenic relationship was studied by quantitative complement-fixation reactions with the virion antigen and homologous antiserums. The complement-fixation curves observed in cross-reactions indicated close antigenic similarity between these two leukemia viruses. Highly purified viral preparations contained detectable amounts of host antigens.