Chromium-51 Ethylenediaminetetraacetate for Estimation of Glomerular Filtration Rate

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Science  20 May 1966:
Vol. 152, Issue 3725, pp. 1076-1077
DOI: 10.1126/science.152.3725.1076


Renal clearances of inulin and chromium-51 ethylenediaminetetraacetate were compared in sheep. In 41 clearance periods from five animals the mean clearance ratio of the chelate to inulin was 0.95 ± 0.03 (S.D.). Part of the difference between the two sets of results may have been due to binding of the metal chelate by plasma protein since 1.5 to 2 percent of chromium-51 ethylenediaminetetraacetate in plasma could not be removed by dialysis.