N-Acetylhistidine Isolated from Frog Heart

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Science  27 May 1966:
Vol. 152, Issue 3726, pp. 1241-1242
DOI: 10.1126/science.152.3726.1241


A diazo-positive comitpound was found in an extract of frog heart. This substance showed a negative ninhydrin reaction and had on a paper chromatogram developed with a phenol-hydrochloric acid solvent system a higher RF than carnosine. The substance, isolated by chrolnatography, was identified as N-acetyl-L-histidine.