Effect of Interferon on Early Interferon Production

See allHide authors and affiliations

Science  27 May 1966:
Vol. 152, Issue 3726, pp. 1274-1276
DOI: 10.1126/science.152.3726.1274


Chick embryo cells given prior treatment with interferon make new interferon earlier and in larger quantities upon stimulation with Chikungunya virus than cells not so treated. By the criterion of loss of sensitivity to actinomycin, the time needed for formation of messenger RNA for interferon was decreased in the primed cells. Thus interferon affects virus action within 1 hour after infection.