Mast Cells and Necrosis

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Science  03 Jun 1966:
Vol. 152, Issue 3727, pp. 1371-1372
DOI: 10.1126/science.152.3727.1371


Subcutaneous injections of normally well tolerated amounts of hypertonic NaCl or urea solutions produce extensive topical necroses in rats systemically treated with various mast-cell dischargers and mast-cell products. This response is considered to be closely related to mitast-cell function, for it cannot be duplicated by systemic treatment with a variety of other agents.