Chloroquine: Physiological Basis of Drug Resistance in Plasmodium berghei

Science  03 Jun 1966:
Vol. 152, Issue 3727, pp. 1374-1375
DOI: 10.1126/science.152.3727.1374


Mouse erythrocytes, parasitized by chloroquine-sensitive plasmodia, concentrate this drug in vivo to levels over twice as high as erythrocytes parasitized by chloroquine-resistant plasmodia; nonparasitized red cells accumulate little chloroquine. Selective toxicity of this drug may depend upon a special drug-concentrating mechanism of plasmodic impairment of such mechanism.