Protective Action of Polycyclic Hydrocarbons against Induction of Adrenal Necrosis by Dimethylbenzanthracene

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Science  03 Jun 1966:
Vol. 152, Issue 3727, pp. 1375-1376
DOI: 10.1126/science.152.3727.1375


Treatment of rats with certain polycyclic hydrocarbons shifts the hydroxylation of dimethylbenzanthracene (DMBA) by liver microsomes from the side-chain to the ring. Protection by these hydrocarbons against dimethylbenzanthracene-induced adrenal necrosis is possibly achieved by decreasing the yield of the 7-hydroxymethyl derivative of dimethylbenzanthracene which may act as the necrotic agent by virtue of its strutctural resemblance to the adrenocortical steroids.