Lymphoid Cells Producing Antibody Against Simple Haptens: Detection and Enumeration

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Science  03 Jun 1966:
Vol. 152, Issue 3727, pp. 1378-1379
DOI: 10.1126/science.152.3727.1378


Enumeration of cells producing antibody against arsanilic acid was made feasible by the use of hapten-conjugated sheep erythrocytes for the localized hemolysis-in-gel technique. The time of appearance and numbers of these hapten-specific plaque-forming cells correlated closely with the development of arsanilic acid-specific serum antibodies.