Influenza Virus Purification with the Zonal Ultracentrifuge

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Science  03 Jun 1966:
Vol. 152, Issue 3727, pp. 1379-1381
DOI: 10.1126/science.152.3727.1379


Sufficient amounts of influenza virus (density, 1.185; size, 722S) can be highly purified (22,000 chicken cell agglutinating units per milligram of protein) with a zonal ultracentrifuge, used first in a rate process followed by isopycnic banding, to permit its detailed biological and physical-chemical evaluation.