Reports

Puromycin Analogs: Action of Adrenocorticotropic Hormone and the Role of Glycogen

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Science  03 Jun 1966:
Vol. 152, Issue 3727, pp. 1386-1388
DOI: 10.1126/science.152.3727.1386

Abstract

The effect of the injection into rats of analogs of puromycin, 6-dimethylaminopurine, and the aminonucleoside of puromycin on the stimullation of steroidogenesis by adrenocorticotropic hormone was coin pared with that of puromycin and cycloheximide. This stimulation was blocked only by the antibiotics, which also inhibited adrenal protein synthesis. Glycogenolysis is not associated with the primary mechanism of the adrenocorticotropic hormone stimnulation of steroid hormone biosynthesis in rats.