Immunoglobulin Structure: Variation in the Sequence of Bence Jones Proteins

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Science  10 Jun 1966:
Vol. 152, Issue 3728, pp. 1513-1516
DOI: 10.1126/science.152.3728.1513


Analysis of the amino acid sequence of one Bence Jones protein is almost comtplete. Many points of interchange occur in the amino terminal. portion of the molecule relative to partial-sequence data for other proteins. Most, but not all, are, compartible with one-step mutations. Such structural variation in immunoglobulin light chains may result from many related genes.