Light-Chain Heterogeneity of Cold Agglutinins

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Science  10 Jun 1966:
Vol. 152, Issue 3728, pp. 1520-1521
DOI: 10.1126/science.152.3728.1520


Cold agglutinins with specificity to I or to i antigens of humanadult or cord-blood erythrocytes produced during the course of Mycoplasma pneumoniae infection and infectious mononucleosis contain light chains of K and L types. However, cold agglutinin isolated from the serums of patients with chronic cold-agglutinin hemolytic anemia contains only type K light chains. The experimental evidence suggests that some cold agglutinins contain both types of light chains in the same molecule.