Tritiated Norepinephrine: Release from Brain Slices by Electrical Stimulation

Science  17 Jun 1966:
Vol. 152, Issue 3729, pp. 1630-1631
DOI: 10.1126/science.152.3729.1630


Slices of rat brain and heart that had concentrated H3-norepinephrine were superfused and electrically stimulated. Stimulation induced a marked release of H3-norepinephrine with a threshold and a maximum repsonse. Release also occurred with increased concentrations of potassium, presumably due to neuronal depolarization. Inhibition of electrically induced release occurred with low calcium and with chlorpromazine and pentobarbital.