Staining Tissue for Light and Electron Microscopy by Bridging Metals with Multidentate Ligands

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Science  17 Jun 1966:
Vol. 152, Issue 3729, pp. 1631-1634
DOI: 10.1126/science.152.3729.1631


"Osmium black," a pigment very useful for cytological staining in both light and electron microscopy, may be deposited selectively at the tissue-binding sites of other metal ions by bridging OsO4 to the tissue bound metal ion through a multidentate ligand.