Cytochemical Localization of Lactate Dehydrogenase in Muscular Dystrophy of the Mouse

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Science  24 Jun 1966:
Vol. 152, Issue 3730, pp. 1761-1763
DOI: 10.1126/science.152.3730.1761


By use of phenazine methosulfate and the "ncubation mixture film method," lactate dehydrogenase activity has been demonstrated in the dystrophic muscle fibers of strain 129 mice. The results indicate that for demonstration of lactate dehydrogenase activity in dystrophic muscle fibers phenazine methosulfate is necessary. This finding is typical for the "white" muscle fibers in the normal muscle and suggests that the dystrophy affects primarily the "white" muscle fibers.