Lipid Films as Transducers for Detection of Antigen-Antibody and Enzyme-Substrate Reactions

Science  08 Jul 1966:
Vol. 153, Issue 3732, pp. 185-188
DOI: 10.1126/science.153.3732.185


The transverse electrical impedance of thin lipid films separating two aqueous saline solutions containing a small concentration of antibodies or enzymes decreases markedly and reversibly after immunological and enzymatic reactions involving such protein molecules, which presumably are adsorbed to the lipid-water interface.