Myotonic Response Induced by Inhibitors of Cholesterol Biosynthesis

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Science  15 Jul 1966:
Vol. 153, Issue 3733, pp. 312-313
DOI: 10.1126/science.153.3733.312


Steroid inhibitors of cholesterogenesis containing nitrogen-substituted side chains induced electromyographic myotonia in rats. Cholesterol reduction or desmosterol accumulation, per se, did not cause myotonia, and cholestrol feeding prevented drug-induced myotonia. Desmosterol accumulation in combination with a specific drug effect may cause the observed myotonia.