Formylmethionine Codon AUG as an Initiator of Polypeptide Synthesis

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Science  22 Jul 1966:
Vol. 153, Issue 3734, pp. 416-418
DOI: 10.1126/science.153.3734.416


Oligonucleotide messengers containing the sequence AUG at or near the 5' end of the chain stimulate the incorporation of N-formylmethionine,but not of free (unformylated) methionine. AUG is considerably more active in this regard than UUG, the other N-formylmethionine codon. The coding activity of subsequent in-phase triplets in the 3' direction from AUG is markedly stimulated by this codon.