Hepatic Synthesis of Alpha2 (Acute Phase)-Globulin of Rat Plasma

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Science  29 Jul 1966:
Vol. 153, Issue 3735, pp. 547-548
DOI: 10.1126/science.153.3735.547


Synthesis of plasma alpha2 (acute phase)-globulin was demonstrated in isolated perfused rat liver obtained from animals showing acute inflammatory reaction to injury. These findings indicate that the liver is a source of the globulin and that appearance of this protein in the serum results from de novo synthesis by the liver rather than from release of performed and stored globulin.