Immunoglobulin M Allotypes of the Rabbit: Identification of a Second Specificity

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Science  05 Aug 1966:
Vol. 153, Issue 3736, pp. 641-643
DOI: 10.1126/science.153.3736.641


Rabbit antiserums, originally prepared to react specifically with rabbit immunoglobulin allotypes Ab5 and Ab6, also react with some normal rabbit serums that clearly do not contain Ab5 or Ab6 allotypes. This reaction is due to antigenic specificity present on rabbit immunoglobulin M(IgM) and not on rabbit immunoglobulin G.Serums that contain this IgM allotype do not react with an antiserum that reacts with the known rabbit IgM allotype, Ms1. This specificity may therefore be identified as a second rabbit IgM allotype, Ms2.