Hemopoietic Colony-Forming Units in Regenerating Mouse Liver: Suppression by Anticoagulants

See allHide authors and affiliations

Science  05 Aug 1966:
Vol. 153, Issue 3736, pp. 643-644
DOI: 10.1126/science.153.3736.643


After hepatic injury induced by carbon tetrachloride, mitotically active hematopoietic cells of nonhepatic origin localize in the liver as judged by an increase in colony-forming nodules in the spleens of lethally irradiated recipient mice on intravenous injection of cells from these livers. The administration of warfarin suppresses the localization of colony-forming units in the regenerating liver by inhibiting the coagulation mechanism of the donor animals.