Glucose-6-Phosphate Dehydrogenase: Homologous Molecules in Deer Mouse and Man

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Science  26 Aug 1966:
Vol. 153, Issue 3739, pp. 1013-1015
DOI: 10.1126/science.153.3739.1013


Two forms of glucose-6-phosphate dehydrogenase, A and B, have been reported in deer mouse tis sues. The B enzyme, which showed autosomally controlled polymorphism, is now found to be equally active to ward glucose-6-phosphate and galac tQse-6- phosphate; the A enzyme is specific for the former. Human and horse livers also have two forms of glucose-6-phosphate dehydrogenase which exhibit the same substrate spe cifities as those in the deer mouse. A wide variety of electrophoretic patterns was seen in the human galactose-active enzyme.