Reports

Diabetes, a New Mutafton in the Mouse

Science  02 Sep 1966:
Vol. 153, Issue 3740, pp. 1127-1128
DOI: 10.1126/science.153.3740.1127

Abstract

Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.

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