Methylene-C14-Dioxyphenyl Compounds: Metabolism in Relation to Their Synergistic Action

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Science  02 Sep 1966:
Vol. 153, Issue 3740, pp. 1130-1133
DOI: 10.1126/science.153.3740.1130


The methylene-C14 group is hydroxylated yielding formate-C14 in the microsome-reduced nicotinamide-adenine dinucleotide phosphate system in vitro and yielding expired C14O2, in living mice and houseflies. Methylenedioxyphenyl compounds apparently serve as alternate substrates for this enzymatic hydroxylation system of microsomes, and thus reduce the rate of metabolism and prolong the action of certain drugs and insecticide chemicals.