Antiserum to Lymphocytes: Prolonged Survival of Canine Renal Allografts

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Science  09 Sep 1966:
Vol. 153, Issue 3741, pp. 1264-1267
DOI: 10.1126/science.153.3741.1264


A horse immunized with dog lynmphocytes produced an antiserum which agglutinated canine lymphocytes in vitro and caused prolonged lymphopenia in dogs in vivo. Renal transplants in dogs treated with this antiserum survived for long periods, two of the grafts surviving beyond 350 days with normal function and histologic appearance.