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N-Cyclohexyl Linoleamide: Metabolism and Cholesterol-Lowering Effect in Rats

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Science  09 Sep 1966:
Vol. 153, Issue 3741, pp. 1267-1269
DOI: 10.1126/science.153.3741.1267

Abstract

More than half of orally administered N-cyclohexyl linoleamide-car-boxyl-C14 yl-CI was recovered from feces of rats, and 30 to 50 percent of the absorbed carbon-14 activity was excreted in urine. N-Cyclohexyl linoleamide had an inhibitory eflect on the absorption of cholesterol from the thoracic duct and caused a decrease in the deposition of cholesterol in the livers of rats that had been fed cholesterol.

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