DNA Synthesis and Differentiation in Embryonic Kidney Mesenchyme in vitro

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Science  16 Sep 1966:
Vol. 153, Issue 3742, pp. 1387-1389
DOI: 10.1126/science.153.3742.1387


Mitosis accompanies the differentiation of embryonic metanephrogenic mesenchyme in vitro. Inhibition of mitosis by 5-fluorodeoxyuridine, but not by x-rays, is associated with inhibition of differentiation. The difference may be due to the effect of 5-fluorode-oxyuridine on DNA synthesis.