Aminooxyacetic Acid: Interactions with Gamma-Aminobutyric Acid and the Blood-Brain Barrier

See allHide authors and affiliations

Science  30 Sep 1966:
Vol. 153, Issue 3744, pp. 1668-1670
DOI: 10.1126/science.153.3744.1668


The hypothesis that the administration of aminooxyacetic acid, a competitive inhibitor of aminobutyrate aminotransferase, might allow γ-aminobutyric acid to cross the blood-brain barrier was tested by analyzing the brains of rats for this compound after intraperitoneal injection of aminooxyacetic acid, or a mixture of both acids, and by observing behavioral and physiological changes in cats after similar drug administrations. The results do not support the postulate that γ-aminobutyric acid enters the brain more readily after administration of aminooxyacetic acid.