Thyroglobulin: Evidence for Crystallization and Association

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Science  30 Sep 1966:
Vol. 153, Issue 3744, pp. 1671-1672
DOI: 10.1126/science.153.3744.1671


Crystals of thyroglobulin have been obtained from ammonium sulfate solutions and have been examined by electron microscopy as shadowed carbon replicas. Unit size in the crystal is 228 ± 9 angstroms, which corresponds to a molecular weight of 5,300,000. Data are in accord with the possibility that this unit represents a polymer of thyroglobulin.