Rheumatic-like Cardiac Lesions in Mice

Science  14 Oct 1966:
Vol. 154, Issue 3746, pp. 285-287
DOI: 10.1126/science.154.3746.285


A single intraperitoneal injection of a sterile extract of sonically disrupted group A streptococcal cells induced an inflammatory process in the hearts of mice. The cardiac lesions, in terms of their distribution and histological features, are similar to the cardiac lesions of rheumatic fever.