Light Chains of Mouse Myeloma Proteins: Partial Amino Acid Sequence

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Science  21 Oct 1966:
Vol. 154, Issue 3747, pp. 391-393
DOI: 10.1126/science.154.3747.391


Five kappa chains in the urinary proteins of the BALB/c mouse have the same carboxyl terminal amino acid sequence; this sequence resembles that of kappa light chains in human immunoglobulins. The five chains have amino acid sequence variations at the amino- terminal. The genetic basis for the amino- terminal variations is not understood but could be due either to a mecha nism for differently translating a single genetic message or to the presence of more than one kappa- type structural cistron in the BALB/c genome.