Carbamylation and Binding Constants for the Inhibition of Acetylcholinesterase by Physostigmine ( Eserine)

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Science  21 Oct 1966:
Vol. 154, Issue 3747, pp. 400-402
DOI: 10.1126/science.154.3747.400


The kinetic treatment and experimental procedures which have been used to evaluate the binding and phosphorylation rate constants of organophos phate inhibitors were applied to the carbamate inhibitor eserine. The binding constant KIcarbamylation rate constant k2efor the inhibition of acetyl cholinesterase by eserine were successfully evaluated.