Hydrogen Bonding Specificity of Nucleic Acid Purines and Pyrimidines in Solution

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Science  28 Oct 1966:
Vol. 154, Issue 3748, pp. 518-520
DOI: 10.1126/science.154.3748.518


The hydrogen bonding of derivatives of guanosine and of cytidine soluble in chloroform has been studied in the infrared. These molecules associate with themselves, but from stronger complexes with each other. Earlier work showed that a similar association occurs between derivatives of adenine and of uracil. A study of all possible interactions of these purines and pyrimidines as pairs shows that guanosine and cytidine and adenine and uracil are the only associating, mixed dimer pairs. These interactions thus reinforce the geometrical specificity seen in the two-stranded nucleic acids.