Pyruvate Inhibition of Lactate Dehydrogenase Activity in Human Tissue Extracts

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Science  28 Oct 1966:
Vol. 154, Issue 3748, pp. 527-529
DOI: 10.1126/science.154.3748.527


Pyruvate inhibition of lactate dehydrogenase activity of crude human tissue extracts has been studied at both 25 ° and 37 °C. The lactate dehydrogenase activity of tissues containing predominantly the slower moving isoenzymes is inhibited significantly less than that of other tissues. These findings are not in accordance with some recently reported.