Polymorphism of Heavy-Chain Genes in Immunoglobulins of Wild Mice

Science  28 Oct 1966:
Vol. 154, Issue 3748, pp. 535-537
DOI: 10.1126/science.154.3748.535


The serums of 123 wild mice from six different geographic locations in the United States contain five of the six known heavy-chain antigenic determinants that have been identified in immunoglobulin of inbred laboratory strains of mice. On the basis of the distribution of determinants in inbred strains,44 of the mice were judged to be heterozygotes of various combinations and two had combinations of determinants that were unusual and could only have occurred in laboratory inbred mice by recombination.