Antibody-Forming Cells: Population Patterns after Simultaneous Immunization with Different Isoantigens

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Science  04 Nov 1966:
Vol. 154, Issue 3749, pp. 655-657
DOI: 10.1126/science.154.3749.655


Spleen cells were obtained from chickens stimulated simultaneously with different erythrocytic antigens, and the proportions producing one and two antibodies were determined by the hemolytic-plaque technique. Most cells from birds immunized with two antigens of the same system (B) appeared to produce only one antibody. In a population of cells from birds immunized with antigens of different systems (A and B), a relatively high proportion of cells produced two antibodies.