Staphylococcal Alpha-Toxin: Effects on Artificial Lipid Spherules

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Science  11 Nov 1966:
Vol. 154, Issue 3750, pp. 772-774
DOI: 10.1126/science.154.3750.772


Staphylococcal alpha-toxin induces the release of previously sequestered anions or glucose from artificial phospholipid spherules, an effect abolished by specific antitoxin. Alphatoxin resembles streptolysin S in releasing anions or glucose from spherules prepared without cholesterol, and can be distinguished from the membrane-active polyene amphotericin B, which preferentially disrupts spherules containing cholesterol. It may affect biological structures by a similiar interaction with membrane phospholipids.