Antigenic Determinants Common to Human Immunoglobulins G and M: Importance of Conformational Antigens

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Science  11 Nov 1966:
Vol. 154, Issue 3750, pp. 790-791
DOI: 10.1126/science.154.3750.790


Antiserums produced against certain isolated human myeloma IgGglobulins and absorbed in order to show only individual antigenic specificity crossreact with certain Waldenstrom IgM-globulins. Some of the common antigenic determinants revealed by these cross-reactions depend on the tertiary and quaternary structure of the IgG and IgM molecules and are independent of their K and L light-chain antigenic types.