Nucleohistone Dissociation by Ganglioside Micelles

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Science  18 Nov 1966:
Vol. 154, Issue 3751, pp. 896-897
DOI: 10.1126/science.154.3751.896


The sialic acid-containing glycosphingolipids known as gangliosides can reverse the heat stabilization of DNA by histones. The ability of pure mono-and disialogangliosides to dissociate reconstituted nucleohistone is directly dependent on their sialic acid content; they are effective in concenitrations above their critical micelle concentration.