Nucleotide Formation as a Determinant of 5-Fluorouracil Response in Mouse Leukemias

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Science  18 Nov 1966:
Vol. 154, Issue 3751, pp. 911-913
DOI: 10.1126/science.154.3751.911-a


Survival of mice bearing different transplantable leukemias and treated with 5-fluorouracil was compared with accumulation of drug nucleotides in vitro. There was significant correlation,suggesting that cellular capacity for conversion of the drug to nucleotides is a major determinant of inherent drug sensitivity of these leukemias.