Glucagon, Starvation, and the Induction of Liver Enzymes by Hydrocortisone

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Science  16 Dec 1966:
Vol. 154, Issue 3755, pp. 1461-1462
DOI: 10.1126/science.154.3755.1461-a


Glucagon selectively potentiates an effect of hydrocortisone: when injected into adrenalectoinized rats it increases fourfold the induction by hydrocortisone of tyrosine transaminase, but not of tryptophan pyrrolase. Glucagon alone doubles the basal level of tyrosine transaminase and decreases that of tryptophan pyrrolase. The effects of glucagon on both enzymes resemble those of starvation.