Naturally Occurring Antimetabolite Antibiotic Related to Biotin

See allHide authors and affiliations

Science  30 Dec 1966:
Vol. 154, Issue 3757, pp. 1667-1668
DOI: 10.1126/science.154.3757.1667


A crystalline antibiotic produced by Streptomyces lydicus has been isolated and shown to be the hitherto unknown αa-dehydrobiotin (I). This is active against a variety of grampositive and gram-negative bacteria and fungi. Its antimicrobial activity is reversed by the presence of biotin in growth media.