Reports

Naturally Occurring Antimetabolite Antibiotic Related to Biotin

Science  30 Dec 1966:
Vol. 154, Issue 3757, pp. 1667-1668
DOI: 10.1126/science.154.3757.1667

Abstract

A crystalline antibiotic produced by Streptomyces lydicus has been isolated and shown to be the hitherto unknown αa-dehydrobiotin (I). This is active against a variety of grampositive and gram-negative bacteria and fungi. Its antimicrobial activity is reversed by the presence of biotin in growth media.

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