Reports

Tyrosinase Inhibition: Its Role in Suntanning and in Albinism

Science  13 Jan 1967:
Vol. 155, Issue 3759, pp. 198-200
DOI: 10.1126/science.155.3759.198

Abstract

Tyrosinase inhibitor (molecular weight less than 5000; extracted from various melanomas) fully inhibits soluble tyrosinase but only partially inhibits tyrosinase "aggregated" into melanosomes; the inhibitor can be inactivated by ultraviolet light. S91 Albinotyrosinase Type B apparently cannot "aggregate" into melanosomes because its protein carrier is genetically altered. Therefore, albinotyrosinase remains vulnerable to its inhibitor and cannot produce melanin, even though the enzyme has a functioning active center.

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