Psilocybin: Reaction with a Fraction of Rat Brain

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Science  13 Jan 1967:
Vol. 155, Issue 3759, pp. 207-208
DOI: 10.1126/science.155.3759.207


Psilocybin, a hallucinogen, formed a blue color with a subfraction of rat-brain mitochondria believed to contain nerve-ending particles. Color formation increased with pH, did not require oxygen, and involved a component that could not be solubilized. The effect was not shown by chemically related neuroactive compounds, such as bufotenine and serotonin, and was antagonized by only tyramine or ethylenediaminetetraacetic acid.