Diphenamid Metabolism in Plants

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Science  13 Jan 1967:
Vol. 155, Issue 3759, pp. 210-211
DOI: 10.1126/science.155.3759.210


Diphenamid, a herbicide, is metabolized to N-methyl 2,2-diphenylacetamide and 2,2-diphenylacetamide by the common soil fungi Trichoderma viride and Aspergillus candidus within 48 hours. The two metabolites are more toxic than diphenamid to both tomato and barnyard-grass seedlings under sterile conditions. This finding indicates that the phytotoxic moiety is not diphenamid but one of its metabolites-probably the N-methyl derivative.