L-Asparaginase:Toxicity to Normal and Leukemic Human Lymphocytes

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Science  20 Jan 1967:
Vol. 155, Issue 3760, pp. 329-330
DOI: 10.1126/science.155.3760.329


Quantitative in vitro tests showed that purified preparations of L-asparaginase from Escherichia coli were more toxic to blood lymphocytes from 12 of 15 patients with chronic lymphocytic leukemia than to lymphocytes from 25 persons with normal hemograms. Incubation for 7 days with 10 units per milliliter killed, on the average, 77 percent of leukemic and 34 percent of normal lymphocytes. The reagent produced appreciable toxicity to leukemic lymphocytes after 2 days of incubation.